Vascular Abnormalities and Elevated Blood Pressure in Mice Lacking Adrenomedullin Gene
نویسندگان
چکیده
Takayuki Shindo, MD, PhD; Yukiko Kurihara, MD, PhD; Hiroaki Nishimatsu, MD, PhD; Nobuo Moriyama, MD, PhD; Masao Kakoki, MD, PhD; Yuhui Wang, MD; Yasushi Imai, MD, PhD; Aya Ebihara, MD, PhD; Tomoyuki Kuwaki, PhD; Ki-Hwan Ju, PhD; Naoto Minamino, PhD; Kenji Kangawa, PhD; Takatoshi Ishikawa, PhD; Minoru Fukuda; Yoshihiro Akimoto, PhD; Hayato Kawakami, PhD; Tomihiko Imai, MD, PhD; Hiroyuki Morita, MD, PhD; Yoshio Yazaki, MD, PhD; Ryozo Nagai, MD, PhD; Yasunobu Hirata, MD, PhD; Hiroki Kurihara, MD, PhD
منابع مشابه
Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene.
BACKGROUND Adrenomedullin (AM) is a vasodilating peptide involved in the regulation of circulatory homeostasis and in the pathophysiology of certain cardiovascular diseases. Levels of AM are markedly increased in the fetoplacental circulation during pregnancy, although its function there remains unknown. To clarify the physiological functions of AM, we chose a gene-targeting strategy in mice. ...
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Adrenomedullin, a recently identified potent vasodilator, is expressed widely and has been suggested to have functions ranging from reproduction to blood pressure regulation. To elucidate these functions and define more precisely sites of Adm expression, we replaced the coding region of the Adm gene in mice with a sequence encoding enhanced green fluorescent protein while leaving the Adm promot...
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Adrenomedullin (AM) levels are elevated in cardiovascular disease, but little is known of the role of specific receptor components. AM acts via the calcitonin receptor-like receptor (CLR) interacting with a receptor-activity-modifying protein (RAMP). The AM1 receptor is composed of CLR and RAMP2, and the calcitonin gene-related peptide (CGRP) receptor of CLR and RAMP1, as determined by molecula...
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Adrenomedullin (AM) is a vasodilating peptide involved in the regulation of circulatory homeostasis and in the pathophysiology of certain cardiovascular diseases. AM plays critical roles in blood vessels, including regulation of vascular stability and permeability. To elucidate the autocrine/paracrine function of AM in endothelial cells (EC) in vivo, a conditional knockout of AM in EC (AM(EC-KO...
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